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For melanoma that has spread to the brain, immunotherapy with nivolumab plus ipilimumab

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

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Inadequate synthesis of carnitine produces carnitine depletion in dialysis patients, resulting in carnitine depletion and a simultaneous relative rise in esterified carnitine in certain individuals (Matera et al., 2003)
