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the degree depends on which variant is present

doi: 10.1007/s00203-022-03142-y [DOI] [PubMed] [Google Scholar] 40.Lin LT, Chung CY, Hsu WC, et al

Points against their use depend on the side effects due to the deep suppression of estrogen production, like hot flashes and bone loss, often needing the use of add-back therapy for long treatments (when more than 6 months long), consisting of supplementation of hormones to reduce these negative consequences [66]

Glutathione is generally well-tolerated but may interact with certain medications or worsen symptoms in G6PD deficiency and some autoimmune conditions
