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20, p = 0.015)

In another report, two polysaccharide fractions, IA-a and IA-b, stimulated cytokine production and phagocytosis, the mycelial culture significantly upregulated IL-2 and TNF- expression and production in murine and human immune cells, suggesting activation of Th-type cell-mediated immune response in vitro [41]

The patients treatment timeline is shown in Figure 2A , illustrating the rapid progression of her disease despite progestin treatment

Notably, serum MDA levels were elevated at all melanoma stages, with the highest levels being observed in stage IV patients, thus suggesting a direct correlation between tumor stage and LPO levels [111]