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639 Edaravone is a free radical scavenger with brain protective effect

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A recent study confirmed that among 1201 patients with NSCLC, more than 60% of initial responders to PD-L1 blockade relapse, and adaptive resistance to PD-L1 blockade in NSCLC is associated with ongoing but altered inflammation and IFN signaling [83]

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60,61 A third redox-sensitive pathway groupincluding Wnt/-catenin, PI3K/AKT/mTOR, aryl hydrocarbon receptor (AhR), TGF-, calcium signaling, Janus kinase (JAK)/signal transducers and activators of transcription (STAT), hypoxia-inducible factor 1 (HIF1), NF-B, Nrf2, c-Jun N-terminal kinase (JNK), p38, and Ataxia-telangiectasia mutated (ATM)features components that shuttle between the cytoplasm and nucleus, allowing complex regulation of gene expression and cellular fate

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doi: 10.1136/jcp.2007.048868 25 DucyPZhangRGeoffroyVRidallALKarsentyG

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