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The clinical manifestations of AA range from localized well-defined patches of alopecia to widespread hair loss of the entire scalp (alopecia totalis, AT) or body (alopecia universalis, AU)

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Senescence is triggered by various intrinsic and extrinsic factors, including DNA damage, telomere attrition, oncogene activation, and oxidative stress, as illustrated in Figure 1

Durch die Aktivierung der Telomerase kann Epithalon : Die Telomere verlngern und so die Lebensdauer der Zellen erhhen