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Skin lightening &

FIGURE 5 2.3 The role of HIF-1 in immune cells: regulation of inflammatory responses 2.3.1 Macrophages HIF-1 plays a pivotal role in regulating macrophage function during bone infection and inflammation

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Activation and nuclear translocation of the primary transcription factor Nrf2 promote the expression of these enzymes, providing robust protection against oxidative damage [44]