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Fat emulsion as an energy source leads to increased production of heat production, reduced respiration ratio, and increased oxygen consumption

The decrease of SCFAs can lead to intestinal inflammation and the loss of nutrition The most abundant short-chain fatty acids (SCFAs) in the human colon are acetate, propionate, and butyrate, can supply energy to cells in the colon, possess anti-inflammatory properties, and protect epithelial barrier integrity [138,139,140]

Glutamine-deprived T-cells have also been shown to differentiate into FoxP3+ Tregs instead of Th1 helper cells, a defect that could be circumvented by simply feeding cells the cell-permeable -KG (33)

The procedure takes only a few minutes, and any mild tenderness at the injection site usually subsides quickly
