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The ATP7B-KO cell line with stable PRNP knockdown (ATP7B-KO:PRNP-KD) was generated by infecting ATP7B-KO cells with pLKO1-puro-CMV-tGFP shPRNP-lentiviral particles (Mission lentiviral transduction particles, SigmaAldrich) and upon selection with puromycin

Dong J, Wang W, Zhou W, Zhang S, Li M, Li N

Semaglutide activates GLP-1 receptors, enhancing insulin secretion, suppressing glucagon, and reducing appetite through one set of neural pathways

According to P-score, oral rivastigmine (OR=1.26, 95% CI: 0.82 to 1.94, P-score=16%) and donepezil (OR=1.08, 95% CI: 0.87 to 1.35, P-score=30%) had the least favourable safety profile, but none of the estimated treatment effects were sufficiently precise when compared with placebo (45 RCTs, 15 649 patients