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Nicotinamide N-methyltransferase (NNMT), an enzyme involved in fat synthesis and energy metabolism, is inhibited by 5-Amino-1MQ
The choice of the best approach for the construction of cereblon-based PROTACs depends on factors such as the availability and cost of the building blocks, or the number of steps and purification processes required to obtain the final compound
However, its efficiency makes it popular in clinical settings
