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The ROS family produced significantly by oxidative stress can activate Caspase1 and GSDMD, accompanied by the release of a large number of pro-inflammatory factors, thereby inducing cell pyroptosis

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There are groups of people who believe ALL iodine should be avoided, there are groups who believe that everyone should take massive doses of iodine, and there are people who believe something in the middle

In this context, it seems that the available animal CIPN models are manifestations of gain in sensory functions which measure mainly allodynia, hyperalgesia and neurophysiological alterations in nerve function, whereas many patients, at least in the chronic phase of CIPN also report other symptoms, such as numbness, tingling and ongoing pain