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Description
Microglial activation is a hallmark of AD, initially serving a protective role but becoming detrimental upon chronic stimulation (Li et al., 2021)

Through the application of various approaches, including copper ion chelators, copper ionophores, mitochondrially targeted drugs, gene therapy vectors, and the development of combined treatment platforms, nanodrug delivery can modulate copper ion homeostasis, mitochondrial metabolic disorders, and associated signaling pathways in the context of cuproptosis (Kahlson and Dixon, 2022)

Supports DMPK, toxicology, and follow-up studies on bioactivation pathways
M., Delaidelli, A., Minaker, S
