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In OA animal models, oral or local administration of NAC has been observed to mitigate cartilage damage and pain, closely tied to its role in sustaining GSH levels and inhibiting ferroptosis (92)

In addition, increases in proinflammatory cytokines leads to the formation of amyloid fibrin microclots resistant to fibrinolysis, either by increased production of serum amyloid A (SAA) or by the release of -amyloid (A) peptide by platelets, causing capillary blockage

Funct Integr Genomics 11:293305

A small, six-month trial in non-diabetic HIV-positive patients revealed that metformin therapy reduced abdominal fat accumulation, lowered blood pressure, and raised HDL cholesterol, supporting the cardio-protective role of the drug in this population