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Nature (2012) 485:2425.10.1038/nature11011 12 SandersSJMurthaMTGuptaARMurdochJDRaubesonMJWillseyAJet alDe novo mutations revealed by whole-exome sequencing are strongly associated with autism
A short summary is provided on the diseases related to dysbiosis and showed increased intestinal permeability according to the available literature

The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained
Based on their physical interactions, RSPOs were first described as Wnt signaling agonists 37
