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These findings suggest that targeting epigenetic modifiers and miRNA networks may offer novel therapeutic opportunities ( 2.5 Disrupted proteostasis and autophagy-lysosomal dysfunction The autophagy-lysosomal pathway (ALP) and ubiquitin-proteasome system (UPS) are critical for degrading misfolded proteins

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the latter is hydrolyzed to monoglutamate via a reaction mediated by folate conjugase at the brush border of enterocytes in the proximal small intestine
