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(PubMed) Taylor BA

A change could make things safer and secure the treatment in the long run
Toxin Burden and the GutKidney Axis When the gut barrier weakens (leaky gut), bacterial fragments and toxins seep into the bloodstream, forcing the kidneys to work harder

Indeed, gut dysbiosis, especially related to obesity of high-fat diet, can increase EC activity, thus, determining an increased gut permeability and consequent LPS translocation