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Methods The healing rate of gastrocutaneous fistula in rat (2-mm-diameter stomach defect, 3-mm-diameter skin defect) validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation, and identifies a potential therapy consisting of: (i) stable gastric pentadecapeptide BPC 157 [in drinking water (10 g/kg) (12 ml/rat/day) or intraperitoneally (10 g/kg, 10 ng/kg, 10 pg/kg)], (ii) atropine (10 mg/kg), ranitidine (50 mg/kg), and omeprazole (50 mg/kg), (iii) 6-alpha-methylprednisolone (1 mg/kg) [intraperitoneally, once daily, first application at 30 min following surgery

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In clinical trials, it demonstrated an 86 percent reduction in vertebral fractures compared to placebo, with greater bone mineral density increases than teriparatide at all measured skeletal sites

Aliquoting reconstituted material into single-use volumes at the time of initial reconstitution is the standard research practice