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In clinical practice, combining AE and RE provides complementary benefits, leading to optimal improvements in hepatic and metabolic outcomes
doi: 10.1586/14737175.2013.814930
Drugs that induce CYP3A activity are expected to increase the clearance of elvitegravir and cobicistat, resulting in decreased plasma concentration of cobicistat, elvitegravir, and TAF, which may lead to loss of therapeutic effect of GENVOYA and development of resistance (see Table 5)
Costanzo S, di Niro V, Di Castelnuovo A, Gianfagna F, Donati MB, de Gaetano G, et al
