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In metabolic disease, nutrient overload and ER stress elevate H 2 O 2 /O 2 , coupling lipotoxicity to ferroptotic risk when labile iron expands (Schieber and Chandel 2014)

Relationship to the risk of myocardial infarction in males

However, there are several major limitations to the current studies that require further investigation: 1

regulating deiodinases (DIO) activity and T3 binding to its nuclear receptor in peripheral tissues
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