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In addition to levodopa, DA receptor agonistssuch as pramipexole, ropinirole, and rotigotinecan also be utilized in the treatment of PD, particularly for early-stage patients or in conjunction with levodopa to delay the onset of motor complications (Herz et al., 2015)

Furthermore, in 3xTg transgenic AD model mice and Caenorhabditis elegans models, betaine enhanced synaptic function and alleviated A toxicity (192, 193)

10.1210/en.2002-0164 35 FengW.WebbP.NguyenP.LiuX.LiJ.KarinM.et al

The mechanism and result are similar to that of GSTP and JNK, in that GSTM1 sequesters ASK1 through complex formation and prevents its induction of the pro-apoptotic p38 and JNK portions of the MAPK signaling cascade
