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Chronic poisoning is usually a consequence of a low-dose exposure over a long time period, which might result in irreversible effects such as neoplastic diseases (Wu and Santella, 2012

Rg1 protects cells against apoptosis caused by MPTP by increasing Bcl-2 and Bcl-xl expression, decreasing Bax and iNOS expression and blocking caspase-3 activation (Chen et al., 2002)

CCK-8, flow cytometry, transwell chambers, enzyme-linked immunosorbent assay (ELISA) and transmission electron microscopy (TEM) were performed for cell growth, apoptosis, migration/invasion, malondialdehyde (MDA)/glutathione (GSH) content and mitochondria damage detection

The combination of 2% 4-hydroxyanisole (Mequinol) and 0.01% tretinoin is effective in improving the appearance of solar lentigines and related hyperpigmented lesions in two double-blind multicenter clinical studies
