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Another important miRNA regulating cell metabolism is miR-378/378*, embedded within gene encoding peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1), a transcriptional regulator of oxidative energy metabolism
Episode 1 Aired Sep 27, 1968 Car for Sale Hacker vows to get even with Carter after Carter cancels their agreement and sells his car to Gomer

And thanks to Thiemo for the question
They frequently present decreased caloric intake and increased metabolic requirements