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For references and more information , see the section on Protein-energy malnutrition (PEM) in the in-depth article on Immunity
doi: 10.1126/scitranslmed.aal3986
Intriguingly, genetic suppression of FBXO22 significantly enhanced HUVEC proliferation and tube formation capacity (Fig
Also, there is a decrease in the expression of pattern recognition receptors (PRR), which leads to the activation of proinflammatory signaling promoting tissue damage (215, 216)
