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[DOI] [PubMed] [Google Scholar] 128.Hamon M, Bierne H, Cossart P

The oxindole scaffold, possessing increased degrees of freedom, exhibited more pronounced conformational changes upon stereochemical inversion, which correlated with larger swings in affinity (Figure 10)

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[41] showed that edaravone dexborneol effectively suppressed nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) inflammation-induced activation of microglial pyroptosis in experimental ischemic stroke through NF-B/NLRP3/gasdermin D (GSDMD) signaling pathway using transient MCAO (tMCAO) mouse model in vivo and oxygen-glucose deprivation (OGD) BV2 cell model in vitro