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In their seminal work, enzymatically responsive PEG macromers were formed by reacting a degradable peptide with PEG, forming an peptide-PEG-peptide block copolymer which was then functionalized with terminal acrylate groups, allowing for hydrogel formation (West and Hubbell, 1999)

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doi: 10.3389/fimmu.2025.1519300 Received 29 October 2024 Accepted 23 January 2025 Published 12 February 2025 Volume 16 - 2025 Edited by John Williams, City of Hope, United States Reviewed by Federico Simonetta, Hpitaux Universitaires de Genve (HUG), Switzerland Nora Heisterkamp, City of Hope, United States Updates Copyright 2025 Horenstein, Faini, Morandi, Ortolan, Storti, Giuliani, Richardson and Malavasi