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It would likely result in extended periods below the MEC, thus wasting the dose and failing to resolve the chronic state [1]
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The ability of CRISPR-Cas9 to specifically inactivate target genes on the bacterial chromosome has been demonstrated in the cases of Staphylococcus aureus [222,223], Clostridioides difficile [224,225], and Klebsiella pneumoniae [226] (Table 4 and Table 5)
