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Direct growth hormone replacement has been explored as a longevity intervention, but it carries meaningful risks, including insulin resistance, fluid retention, carpal tunnel syndrome, and theoretical promotion of existing tumors, because GH and its primary mediator IGF-1 have potent pro-growth signaling that is indiscriminate about what it grows

Despite these promising findings, the precise mechanisms and effects of these extracts remain incompletely understood, and potential side effects must be considered

Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis

Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption