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To address these limitations and further evaluate the therapeutic potential of BCATi in an in vivo setting, we developed a mouse model of MMA, Mmut p.L690Ins/p.L690Ins , that closely mimics the human disease

Most small congenital nevi will show a BRAF mutation

Cross-linked enzyme aggregates The CLE procedure has their catalytic activity reduced if the enzymes immobilized, because they are solubilize in the solution, discussed previously

[9] Prognosis [edit] Large and especially giant congenital nevi are at higher risk for malignancy degeneration into melanoma
