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Knockdown of NLRP3 or caspase-1 reduced neuronal death and reversed cognitive impairments [147], whereas PARP-1 -/- mice were observed to prevent synaptic damage, cognitive dysfunction, and microglial activation in an AD mouse model referring to the significant role of pyroptosis and parthanathos in the pathogenesis of AD [148, 149]

Interestingly, future outcomes involving asthma may be predicted by the nasopharyngeal microbiome

Multiple preclinical studies have identified that BPC-157 increases vascular endothelial growth factor (VEGF) protein and gene expression, a critical pathway in tissue repair and regeneration

Hu J., Dong L., and Outten C.E
