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Nevertheless, NBS can facilitate early treatment and significantly reduce the symptom onset in mut patients, and the lower metabolic indicator levels before treatment in the NBS group of mut-MMA patients indicated that the early diagnosis due to NBS can effectively reduce the occurrence of damaging or even fatal acute metabolic derangement at initial presentation

Intestinal alkaline phosphatase aids this [73]

But its also part of a bigger system: the balance between free carnitine, acylcarnitines, and acyl-CoA, a trade-off game that helps regulate how different substrates are handled inside the cell

Gordon BL, Galati JS, Yang S, et al