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Description
Loss of DOT1L caused a decrease in H3K9me2, resulting in decreased transcription of genes expressed in upper-layer neurons (Satb2, Pou3f3, Cux2, and the Sox family)

10.1007/s11356-017-9662-5 312 WimmerA.MarkusA
While collagen is relatively heat-stable, extreme temperatures can eventually break down the delicate peptide bonds, potentially reducing its effectiveness

Elevate IGF-1 Higher liver-derived IGF-1 drives lipolysis, collagen synthesis, and lean-muscle accrual
