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These metabolic benefits translate into whole-body effects: for example, in diet-induced obesity models, MOTS-c administration prevented excessive weight gain and insulin resistance when mice were fed a high-fat diet, without affecting weight in lean diets
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Tong J, Ang L-C, Williams B, Furukawa Y, Fitzmaurice P, Guttman M, Boileau I, Hornykiewicz O, Kish SJ
