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PEA is thought to work by supporting the inflammatory response through the PPAR-a receptor, COX-2 and through effects on NF-kappaB signaling while also by restoring balance in the endocannabinoid system

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TABLE 2 Oxidative stress markers and mitochondrial NO synthase (mtNOS) activity in heart mitochondria of adult, old and GSH-treated old rats

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These genes regulated by GSTM3 were mainly focused on metabolism, antioxidant activity and signal transduction

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In this study we confirmed that not only collagen type 1 but also CCN4 and LOX are upregulated by ENPP2

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