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For several additional loci, variants were either not present in the available summary statistics or did not reach statistical significance in the external datasets, although some demonstrated directionally consistent effects

205 Additionally, the activation of the TNF receptor-1 (TNF-R1) signaling pathway is involved in the copper-induced extrinsic apoptosis pathway, marked by substantial increases in the mRNA and protein levels of TNF-R1, Fas-associated death domain, TNFR-associated death domain, and cleaved caspase-8

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