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Cognitive fatigability is easily and quickly assessed through TAP (Test for Attention) alertness examinations

Although the findings are not always consistent, changes in the brainstem have been very common, especially structural changes, mainly a decrease in grey or white matter volume in patients, often pronounced in relation to the symptom burden of fatigue, pain and autonomic symptoms

conducted a study involving a smartphone app and sensor (Fitbit) to check the status of the patients during the COVID-19 lockdown, in which they were homebound and social contacts were reduced

For example, in a recent cross-sectional surveillance study conducted in 43 paediatric patients taking VPA [48], only two were found to have carnitine levels below the normal limit, suggesting that routine carnitine level checking is not justified