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With B12 injections, all the dose is delivered into the bloodstream, so you get the maximum benefit

"These topline safety, immunogenicity and efficacy data are encouraging, and we look forward to soon completing our submissions to regulators globally with the hope of making this vaccine available to younger children as quickly as possible, subject to regulatory authorization," Pfizer Chairman and CEO Albert Bourla said in a statement

Moreover, experimental data show that the 5-methylTHFFR- complex is secreted by the choroid plexus as an exosome with several other proteins for uptake from the CSF by the brain parenchyma (80)