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Surgeries such as subacromial decompression (which can involve removing spurs and thickened ligaments as well as resurfacing shoulder bones) and shoulder arthroplasty (which is a replacement of the shoulder joint) often have excellent outcomes but are major procedures that involve a significant investment of time and require extensive rehabilitation

Those results are in a different category of efficacy compared with B12 or many over-the-counter supplements

Vascular (e.g., Endothelin-derived peptides) -blood flow enhancement

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