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doi: 10.3389/fmed.2021.642710 312 YangC-ABauerSHoY-CSotznyFChangJ-GScheibenbogenC

The mechanistic benefits include increased fibroblast activity, improved skin elasticity, enhanced wound healing capacity, and better skin barrier function through ceramide production

Folate (vitamin B9), a carrier of one-carbon units, and other B vitamins, such as B6 and B12, take part widely in one-carbon metabolism, which is requisite for DNA biosynthesis and methylation (51)
The ubiquitinproteasome system (UPS) and autophagy play major roles in degradations of short-lived and long-lived proteins, respectively (Bachmair and Varshavsky, 1989
