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doi: 10.1021/jacs.7b12025
IL-12 and aCTLA-4 were jointly entrapped in RBC to obtain IL&aC@RBAH as control
However, attenuated signaling or cellular tolerance is the sum of multiple processes including: receptor desensitization, receptor resensitization, receptor internalization (recycling or downregulation), de novo receptor synthesis, and Golgi stability, as well as receptor trafficking to the cell membrane (externalization)
Sympathetic stimulation leads to hepatic glucose production by activating glycogenolysis in fed states and gluconeogenesis in fasted states
