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Description
Early studies from the late 1990s reported that supplementation at 12 grams per day improved mood and reduced fatigue in patients with major depressive disorder, as evidenced by reductions in Hamilton Depression Rating Scale scores by about 2030% over 48 weeks [5]

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However, the increase in thigh girth was not significantly different between study conditions

Marked elevation in plasma trimethylamine-N-oxide (TMAO) in patients with mitochondrial disorders treated with oral l-carnitine
