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The idea is that Retatrutide creates a favorable metabolic environment by reducing calorie intake and regulating glucose, while MOTS-c then optimizes the cellular ability to process these changes efficiently

Rapid-acting antidepressant ketamine, its metabolites and other candidates: a historical overview and future perspective

doi:10.1038/sj.ijir.3900582
Note that ABHD5 has 349 residues whereas ABHD4 is 7 amino acids shorter, hence the size difference