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Finally, under the weakly acidic condition characteristic of the TME, HK molecules are released from the NPs in a controlled manner, thereby maintaining a sustained drug concentration within the tumor cells and exerting its cytotoxic effects

To further explore the role of the BM microenvironment in promoting mTOR activity in LTR, we analyzed mTOR expression in the non-CAR T cell fraction in the BM, which is composed of non-transduced T cells from the CAR T cell product as well as endogenous reconstituting T cells

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Currently, there is a general agreement that mitochondrial dysfunction, -synuclein aggregation, oxidative stress, neuroinflammation, and impaired protein degradation are involved in the neurodegeneration of dopaminergic neurons containing neuromelanin in Parkinson's disease