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Hematologic Changes Although no instances of severe hematologic toxicity were seen in the premarketing experience with clomipramine hydrochloride, there have been postmarketing reports of leukopenia, agranulocytosis, thrombocytopenia, anemia, and pancytopenia in association with clomipramine hydrochloride use

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To create the tnaA mutant, the DNA fragment containing the kanamycin resistance cassette for homologous recombination was amplified by PCR using the primers F- tnaA -FRT and R- tnaA -FRT and the plasmid pKD4 as the template
