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Conference Publication:(var Grossberg GT, Manes F, Allegri R, Robledo LMG
Conversely, Nrf2 has been documented to reduce NOX activation and inhibit protein kinase C, consequently leading to a decrease in ROS levels and production in Nrf2-KO mice due to elevated antioxidant GSH levels, highlighting its role in mitigating oxidative stress
This feedback loop further promotes the progression of DKD (Wang and Zhang, 2024)
However, MFAP2 has mostly been studied as a component of the extracellular matrix (ECM) in the context of cancer progression, with limited research on its role in CRC
