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Chemotherapeutic agents and immune checkpoint inhibitors (ICIs) have been shown to activate caspase-3, which subsequently cleaves GSDME, triggering pyroptosis in melanoma cells (75, 78)
The active functional component of glutathione is the thiol (-SH) group located on its cysteine residue
Initiating sermorelin can occasionally unmask or worsen subclinical hypothyroidism, sometimes requiring thyroid dose adjustment
