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3 This is a transcriptional, hours-to-days mechanism layered on top of the acute cAMP/PKA switch, and it depends on an intact growth-hormone receptor signaling apparatus

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JAMA 330, 13701380

However, it is clear that the effects of lower and higher doses of GSHee need to be evaluated against higher doses of fentanyl that are known to cause a more dangerous depression of breathing 121
