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In response to the damage, mitogenic cyokines are secreted and a similar process to wound healing results in rapid cell cycling and rapid maturation of keratinocytes [1, 2, 3].The constant inflammatory cell chemotaxis and cytokine release causes the chronic clinical course with recurrent lesions

For instance, non-biodegradable fillers, such as polymethylmethacrylate (PMMA) or silicone, are more likely to cause long-term complications compared to biodegradable fillers like hyaluronic acid

[Google Scholar] 40.Reznik G.O., Vishwanath P., Pynn M.A., Sitnik J.M., Todd J.J., Wu J., Jiang Y., Keenan B.G., Castle A.B., Haskell R.F., Smith T.F., Somasundaran P., Jarrell K.A