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doi: 10.1016/j.redox.2015.07.012
Freeze-thaw cycling degrades most peptides

Vukojevi et al
Some conditions that require precaution include: Diabetic Retinopathy: In clinical trials, it was observed that brand-name semaglutide can temporarily worsen eye problems in diabetic patients due to sudden hypoglycemia (drops in blood glucose levels), which can worsen diabetic retinopathy
