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Nevertheless, it has been shown that in the humans, the GST with the highest activity toward AFB 1 exo-epoxide is the polymorphic hGSTM1-1 which is absent in about 50% of individuals in most human populations
Circulation 145 , 12051217 (2022)
Akt phosphorylates and inhibits tuberous sclerosis 1 and 2 (TSC1/TSC2), resulting in activation of small G protein Ras homolog enriched in brain (Rheb) via its binding to GTP
Similarly, a closer examination can help the doctor determine whether the condition is benign or malignant
