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Furthermore, enhanced reactive oxygen species (ROS) production after aminoglycoside treatment has been shown to promote apoptotic hair cell death via caspase-3 and nuclear factor kappa (NF-B) activation (Lee et al

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Zafereo ME , Jozaghi Y, Perrier ND, Wang JR, Grubbs E, Gross ND, Fisher S, Sturgis EM, Goepfert RP, Lai SY, Best C, Busaidy NL, Cabanillas ME, Dadu R, Gagel RF, Habra MA, Hu MI, Jimenez C, Sherman SI, Thosani S, Varghese J, Waguespack SG, Weitzman S, Ying AK, Graham PH

A known active attack or presence on an IS where the virus has executed on that system