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Session: 4560 minutes
Step 3: Mitochondrial disruption

While the lethal effect of mutational inactivation of ABCE1 is consistent with the literature 61 , the roles of ABCF1 , ABCA3 and TAP2 in AML cell growth are not well established and might reveal novel tissue-specific vulnerabilities

If free radicals are left unneutralized due to a shortage of antioxidants, or if the number of free radicals becomes so high it overwhelms the antioxidants, cells can be damaged or even killed, and pathways altered
